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has initiated a study to measurs a range of biomarkeer responses in female and male workersz exposedto 1,3 butadiene (BD) in the The funding for the study is being provided by the Olefins Panel of the American Chemistry The amount of the funding was not The study will compare responsesd and susceptibility to 1,3-butadiene, which is used primarily in the synthesid of synthetic rubber and is also a producr of combustion.
The highest exposuresw to butadiene are in workplace settings duringf the manufacture and useof butadiene, but the generalp population is also exposed primarily from combustion sources such as on road and off road In animal bioassays, butadiene causes cancer in mice at exposuree levels of 2 ppm, but no malignanr tumors are observed in rats exposed up to 8,000 ppm. There is controversy as to its potential to causd health effects in Data from the planned study is intendexd to help resolve some ofthesed issues.
The most recent EPA Risk Assessment ofbutadiene (US EPA, is based in part on the premise that women might be more susceptiblew than men to any possible adverse effectzs of this agent. The current study will includd women exposed at the same BD level as men at the same plantt in theCzech Republic, and will compare resultsx between the two sexes. BioMosaics is a privatelt held biotechnology company engaged in the developmenf and commercialization of productse and methods for theearly prediction, monitoring and treatment of cancer and autoimmune
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